A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines

Dendritic spines are the postsynaptic compartments of excitatory neurotransmission. We combined electron microscopy and quantitative biochemistry with super-resolution microscopy to annotate more than 47,000 spines for more than 100 synaptic targets, resulting in a nanoscale 3D model of spines.

Nature Neuroscience 2021

Investigating synapses with super-resolution and expansion microscopy

Leica Microscopy Workshop 2018 - Marburg, Germany

The Dendrite Nanomap - A quantitative 3D nanoscale model of dendritic spines

Selected as dynamic poster presentation

Society for Neuroscience Meeting 2019 - San Diego, USA

Dendritic spine nanomaps

Quantitative Synaptology Meeting 2018 - Göttingen, Germany

WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton

We use super-resolution microscopy to determine the effect of Src kinase phosphorylation on the actin cytoskeleton .

Sci. Rep. 2018